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KMID : 0624620180510080418
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BMB Reports
2018 Volume.51 No. 8 p.418 ~ p.423
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Activation of formyl peptide receptor 2 by WKYMVm enhances emergency granulopoiesis through phospholipase C activity
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Kim Hyung-Sik
Park Min-Young
Lee Sung-Kyun
Park Joon-Seong
Lee Ha-Young
Bae Yoe-Sik
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Abstract
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Emergency granulopoiesis is a very important strategy to supply efficient neutrophil number in response to infection. However, molecular mechanism involved in this process remains unclear. Here, we found that administration of WKYMVm, an immune modulating peptide, to septic mice strongly increased neutrophil number through augmented emergency granulopoiesis. WKYMVm-induced emergency granulopoiesis was blocked not only by a formyl peptide receptor 2 (FPR2) antagonist (WRW4), but also by FPR2 deficiency. As progenitors of neutrophils, Lin?c-kit+Sca-1? cells expressed FPR2. WKYMVm-induced emergency granulopoiesis was also blocked by a phospholipase C inhibitor (U-73122). These results suggest that WKYMVm can stimulate emergency granulopoiesis via FPR2 and phospholipase C enzymatic activity.
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KEYWORD
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Emergency granulopoiesis, Formyl peptide receptor 2, Phospholipase C, WKYMVm
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